Premenstrual Dysphoric Disorder (PMDD)

Premenstrual dysphoric disorder (PMDD) is a severe, disabling form of PMS. In PMDD, the main symptoms are mood disorders such as depression, anxiety, tension, and persistent anger or irritability. These severe symptoms lead to problems with relationships and carrying out normal activities. Women with PMDD usually also have physical symptoms, such as headache, joint and muscle pain, lack of energy, bloating and breast tenderness. According to the American Psychiatric Association, a woman must have at least five of the typical symptoms to be diagnosed with PMDD. The symptoms must occur during the two weeks before her period and go away when bleeding begins.

Research has shown that antidepressants called selective serotonin reuptake inhibitors (SSRIs) can help many women with PMDD. The Food and Drug Administration (FDA) has approved two such medications to date for treatment of PMDD - sertraline (Zoloft) and fluoxetine (Sarafem).